论文标题
能力和机械研究的能力和机械研究，作为小梁骨的结构模型
A Morphological, Topological and Mechanical Investigation of Gyroid, Spinodoid and Dual-Lattice Algorithms as Structural Models of Trabecular Bone
论文作者
论文摘要
在这项研究中，我们通过系统评估形态计量学，拓扑和机械性能评估了三种算法作为小梁骨结构的计算模型的性能。在这里，我们考虑了广泛使用的能状结构，最近发育的旋转固醇结构以及类似于此处引入的Voronoi Lattices的结构。虽然对所有计算模型进行了校准以重新创建小梁组织的体积（例如BV/TV），但发现基于能力和脊柱固醇的结构均显示出许多其他形态计量和拓扑参数的实质性差异，并且与Trabecular Bone相比均显示出较低的有效机械性能。与小梁骨相比，新开发的双晶格结构更好地捕获了形态学参数和机械性能。尽管如此，这些计算算法仍然提供了有用的平台来研究小梁骨力学和设计仿生结构，这些结构可以通过加成制造为包括骨骼替代品，脚手架和多孔植入物的应用而生产。此外，建立结构的软件已添加到开源工具箱长臂猿中，因此可以自由使用。
In this study, we evaluate the performance of three algorithms as computational models of trabecular bone architecture, through systematic evaluation of morphometric, topological, and mechanical properties. Here, we consider the widely-used gyroid lattice structure, the recently-developed spinodoid structure and a structure similar to Voronoi lattices introduced here as the dual-lattice. While all computational models were calibrated to recreate the trabecular tissue volume (e.g., BV/TV), it was found that both the gyroid- and spinodoid-based structures showed substantial differences in many other morphometric and topological parameters and, in turn, showed lower effective mechanical properties compared to trabecular bone. The newly-developed dual-lattice structures better captured both morphometric parameters and mechanical properties, despite certain differences being evident their topological configuration compared to trabecular bone. Still, these computational algorithms provide useful platforms to investigate trabecular bone mechanics and for designing biomimetic structures, which could be produced through additive manufacturing for applications that include bone substitutes, scaffolds and porous implants. Furthermore, the software for the creation of the structures has been added to the open source toolbox GIBBON and is therefore freely available to the community.
