论文标题

具有半透色界面的陷阱的3D狭窄捕获问题

The 3D narrow capture problem for traps with semipermeable interfaces

论文作者

Bressloff, Paul C

论文摘要

在本文中,我们分析了单个布朗粒子在三维(3D)有界结构域中扩散的狭窄捕获问题,该结构域中包含一组小的球形陷阱。每个陷阱的边界表面被视为半透明的膜。也就是说,跨界面的连续通量与概率密度的相关跳跃不连续性成正比。比例的常数用渗透率$κ$确定。此外,我们允许在每个界面之间的扩散性和化学势中不连续。后者引入了方向性偏差。我们还假设粒子可以在每个陷阱的内部吸收(捕获)以某些泊松速率$γ$。在小型陷阱限制中,我们使用匹配的渐近学和Green的功能方法来计算一个陷阱之一吸收的分裂概率和无条件的MFPT。但是,分析的细节取决于各种参数如何用特征陷阱半径$ε$缩放。在尺度下,$γ= O(1/ε^2)$和$κ= O(1/ε)$,我们表明,与完全吸收陷阱的标准示例相比,可半透明的膜减少了每个球形陷阱的有效电容$ \ CARC $。最后,我们考虑了单向极限,在这种极限中,每个接口仅允许粒子流入陷阱。然后,陷阱充当恒定反应率$κ$的部分吸收表面。将渐近分析与部分反应性表面的基于遭遇的表述相结合,我们展示了如何根据电容$ \ calc $分析广义的表面吸收机制(非马克维亚)。因此,我们确定可以根据陷阱的有效电容来表征广泛的狭窄捕获问题。

In this paper we analyze the narrow capture problem for a single Brownian particle diffusing in a three-dimensional (3D) bounded domain containing a set of small, spherical traps. The boundary surface of each trap is taken to be a semipermeable membrane. That is, the continuous flux across the interface is proportional to an associated jump discontinuity in the probability density. The constant of proportionality is identified with the permeability $κ$. In addition, we allow for discontinuities in the diffusivity and chemical potential across each interface; the latter introduces a directional bias. We also assume that the particle can be absorbed (captured) within the interior of each trap at some Poisson rate $γ$. In the small-trap limit, we use matched asymptotics and Green's function methods to calculate the splitting probabilities and unconditional MFPT to be absorbed by one of the traps. However, the details of the analysis depend on how various parameters scale with the characteristic trap radius $ε$. Under the scalings $γ=O(1/ε^2)$ and $κ=O(1/ε)$, we show that the semipermeable membrane reduces the effective capacitance $\calC$ of each spherical trap compared to the standard example of totally absorbing traps. Finally, we consider the unidirectional limit in which each interface only allows particles to flow into a trap. The traps then act as partially absorbing surfaces with a constant reaction rate $κ$. Combining asymptotic analysis with the encounter-based formulation of partially reactive surfaces, we show how a generalized surface absorption mechanism (non-Markovian) can be analyzed in terms of the capacitances $\calC$. We thus establish that a wide range of narrow capture problems can be characterized in terms of the effective capacitances of the traps.

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