论文标题
调整细胞电池通信的范围可实现从棋盘到吞噬的细胞命运图案的微调
Adjusting the range of cell-cell communication enables fine-tuning of cell fate patterns from checkerboard to engulfing
论文作者
论文摘要
在开发过程中，从棋盘到吞噬的时空模式以各自的细胞命运的精确比例发生。关键的发育调节剂是细胞内转录相互作用和细胞间信号传导。我们提出了一个基于信号传导的可分析数学模型，该模型可靠地生成具有指定比例的不同细胞类型模式。使用统计力学，我们得出了两种细胞类型的细胞命运决策模型。对产生的动力学系统的详细稳态分析产生了必要的条件，以产生空间异质模式。这允许单元类型比例由单个模型参数控制。细胞电池通信是通过局部和全局信号传导机制实现的。这些导致不同的细胞类型模式。最近的邻居信号会产生棋盘图案。可以产生增加信号分散，细胞命运簇和吞没模式。总体而言，提出的模型允许可靠地生成不同种类和所需比例的异质细胞类型模式。
During development, spatio-temporal patterns ranging from checkerboard to engulfing occur with precise proportions of the respective cell fates. Key developmental regulators are intracellular transcriptional interactions and intercellular signaling. We present an analytically tractable mathematical model based on signaling that reliably generates different cell type patterns with specified proportions. Employing statistical mechanics, We derived a cell fate decision model for two cell types. A detailed steady state analysis on the resulting dynamical system yielded necessary conditions to generate spatially heterogeneous patterns. This allows the cell type proportions to be controlled by a single model parameter. Cell-cell communication is realized by local and global signaling mechanisms. These result in different cell type patterns. A nearest neighbor signal yields checkerboard patterns. Increasing the signal dispersion, cell fate clusters and an engulfing pattern can be generated. Altogether, the presented model allows to reliably generate heterogeneous cell type patterns of different kinds as well as desired proportions.
