论文标题

放射素增强的深度多任务学习,用于头颈癌的结果预测

Radiomics-enhanced Deep Multi-task Learning for Outcome Prediction in Head and Neck Cancer

论文作者

Meng, Mingyuan, Bi, Lei, Feng, Dagan, Kim, Jinman

论文摘要

结果预测对于头颈癌患者至关重要,因为它可以为早期治疗计划提供预后信息。放射学方法已被广泛用于医学图像预测。但是,这些方法受到对肿瘤区域的顽固性手动分割的限制。最近,已经提出了深度学习方法来执行端到端结果预测,以消除对手动分割的依赖。不幸的是,如果没有分割面膜,这些方法将将整个图像作为输入,从而使它们难以专注于肿瘤区域,并且可能无法完全利用肿瘤区域内的预后信息。在这项研究中,我们提出了一个放射素增强的深度任务框架,以在头颈肿瘤分割和结果预测挑战的背景下,从PET/CT图像预测结果(Hecktor 2022)。在我们的框架中,我们的新颖性是将放射素学纳入我们最近提出的深层多任务生存模型(DEEPMTS)的增强。 DEEPMT共同学会了预测患者的生存风险评分和肿瘤区域的分割口罩。放射素学特征是从预测的肿瘤区域中提取的,并与预测的最终结果预测的生存风险评分相结合,可以通过该预测进一步利用肿瘤区域的预后信息。我们的方法在测试集上达到了0.681的C索引,将第二个位于排行榜上,仅比第一名低0.00068。

Outcome prediction is crucial for head and neck cancer patients as it can provide prognostic information for early treatment planning. Radiomics methods have been widely used for outcome prediction from medical images. However, these methods are limited by their reliance on intractable manual segmentation of tumor regions. Recently, deep learning methods have been proposed to perform end-to-end outcome prediction so as to remove the reliance on manual segmentation. Unfortunately, without segmentation masks, these methods will take the whole image as input, such that makes them difficult to focus on tumor regions and potentially unable to fully leverage the prognostic information within the tumor regions. In this study, we propose a radiomics-enhanced deep multi-task framework for outcome prediction from PET/CT images, in the context of HEad and neCK TumOR segmentation and outcome prediction challenge (HECKTOR 2022). In our framework, our novelty is to incorporate radiomics as an enhancement to our recently proposed Deep Multi-task Survival model (DeepMTS). The DeepMTS jointly learns to predict the survival risk scores of patients and the segmentation masks of tumor regions. Radiomics features are extracted from the predicted tumor regions and combined with the predicted survival risk scores for final outcome prediction, through which the prognostic information in tumor regions can be further leveraged. Our method achieved a C-index of 0.681 on the testing set, placing the 2nd on the leaderboard with only 0.00068 lower in C-index than the 1st place.

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