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We present an efficient, accurate, and comprehensive analysis framework for generic, multi-port nonlinear parametric circuits, in the presence of dissipation from lossy circuit components, based on "quantum-adapted" X-parameters. We apply this method to Josephson traveling-wave parametric amplifiers (JTWPAs) - a key component in superconducting and spin qubit quantum computing architectures - which are challenging to model accurately due to their thousands of linear and nonlinear circuit components. X-parameters are generated from a harmonic balance solution of the classical nonlinear circuit and then mapped to the field ladder operator basis, so that the energy associated with each of the multiple interacting modes corresponds to photon occupancy, rather than classical power waves. Explicit relations for the quantum efficiency of a generic, multi-port, multi-frequency parametric circuit are presented and evaluated for two distinct JTWPA designs. The gain and quantum efficiency are consistent with those obtained from Fourier analysis of time-domain solutions, but with enhanced accuracy, speed, and the ability to include real-world impairments, statistical variations, parasitic effects, and impedance mismatches (in- and out-of-band) seamlessly. The unified flow is implemented in Keysight's PathWave Advanced Design System (ADS) and independently in an open-source simulation code, JosephsonCircuits.jl, from the MIT authors.