论文标题

相互信息辅助合奏推荐系统,用于识别医疗保健预后中的关键风险因素

Mutual Information Assisted Ensemble Recommender System for Identifying Critical Risk Factors in Healthcare Prognosis

论文作者

Dey, Abhishek, Goswami, Debayan, Roy, Rahul, Ghosh, Susmita, Zhang, Yu Shrike, Chan, Jonathan H.

论文摘要

目的:健康推荐人作为重要的决策支持系统,帮助患者和医疗专业人员采取行动,导致患者的幸福感。这些系统提取可能与最终用户特别相关的信息,帮助他们做出适当的决定。本研究提出,作为疾病管理系统的一部分,推荐一个特征,该功能识别并建议疾病最重要的风险因素。 方法:提出了一种新型的相互信息和基于整体的特征排名方法,用于识别医疗保健预后中的关键风险因素。 结果:为了确定所提出方法的有效性,已经在四种不同疾病的基准数据集(透明细胞肾细胞癌(CCRCC),慢性肾脏病,印度肝脏患者和宫颈癌危险因素上进行了实验)。使用推荐系统的性能指标(例如平均精度@k,precision@k,recome@k,k,f1@k,fercomal rack@k)将建议的推荐人的性能与四种最新方法进行比较。该方法能够推荐CCRCC的所有相关关键风险因素。与现有方法相比,它还具有更高的精度(分别使用支持向量机和神经网络的96.6%和98.6%),其功能集降低。此外,使用CCRCC,即使用建议的方法推荐的前两个功能。肿瘤和转移状态的大小从现有TNM系统进行医学验证。还发现其他三个数据集的结果是优越的。 结论:拟议的推荐人可以识别并推荐具有检测疾病最大能力的风险因素。

Purpose: Health recommenders act as important decision support systems, aiding patients and medical professionals in taking actions that lead to patients' well-being. These systems extract the information which may be of particular relevance to the end-user, helping them in making appropriate decisions. The present study proposes a feature recommender, as a part of a disease management system, that identifies and recommends the most important risk factors for an illness. Methods: A novel mutual information and ensemble-based feature ranking approach for identifying critical risk factors in healthcare prognosis is proposed. Results: To establish the effectiveness of the proposed method, experiments have been conducted on four benchmark datasets of diverse diseases (clear cell renal cell carcinoma (ccRCC), chronic kidney disease, Indian liver patient, and cervical cancer risk factors). The performance of the proposed recommender is compared with four state-of-the-art methods using recommender systems' performance metrics like average precision@K, precision@K, recall@K, F1@K, reciprocal rank@K. The method is able to recommend all relevant critical risk factors for ccRCC. It also attains a higher accuracy (96.6% and 98.6% using support vector machine and neural network, respectively) for ccRCC staging with a reduced feature set as compared to existing methods. Moreover, the top two features recommended using the proposed method with ccRCC, viz. size of tumor and metastasis status, are medically validated from the existing TNM system. Results are also found to be superior for the other three datasets. Conclusion: The proposed recommender can identify and recommend risk factors that have the most discriminating power for detecting diseases.

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