论文标题

通过元启发式L1-L1搜索在TES中生成最佳焦点和强烈的电流模式:内点与单纯算法

Generating Optimally Focal and Intense Current Patterns in tES via Metaheuristic L1-L1 Search: Interior-Point vs. Simplex Algorithms

论文作者

Prieto, F. Galaz, Samavaki, M., Pursiainen, S.

论文摘要

这项数值仿真研究研究了解决L1-norm拟合和正则化(L1-L1)线性编程(LP)问题,以找到经颅电刺激(TES)中良好的重新定位的体积电流密度,其中通过接触电极通过接触电极附着于皮肤上,以在靶向脑区域中产生刺激性。我们考虑了选择问题参数的元启发式优化过程,以便发现最终解决方案对于给定的读术术,例如,大脑中体积电流密度的强度和焦点是最佳的。我们专注于LP算法对溶液的影响。我们检查了内点和单纯算法,这构成了解决LP任务的两种主要替代方法。内点算法基于确定可行的解决方案集以允许通过牛顿的方法找到优化器,而单纯形方法则沿多层层的边缘采取步骤,将一组候选解决方案组成的简单多边形分析。内部点方法同时在收敛属性方面具有复杂性和可预测性而脱颖而出。为了找到当前的模式,我们应用了五个替代优化工具箱:Matlab,Mosek,Gurobi,SDPT3和Sucemi。我们建议这些之间的相互差异会根据目标的放置以及两参数晶格的分辨率而有所不同。在数值实验中,我们研究了最大化L1-L1优化刺激电流的焦点和强度,并且在后者方面,研究了其与倒电流模式的关系,从而最大程度地提高了聚焦电流密度。

This numerical simulation study investigates solving the L1-norm fitted and regularized (L1-L1) linear programming (LP) problem to find a well-localized volumetric current density in transcranial electrical stimulation (tES), where a current pattern is attached through contact electrodes attached to the skin to create a stimulus in a targeted brain region. We consider a metaheuristic optimization process where the problem parameters are selected so that the final solution found is optimal with respect to given metacriteria, e.g., the intensity and focality of the volumetric current density in the brain. We focus on the effect of the LP algorithm on the solution. We examine interior-point and simplex algorithms, which constitute two major alternative ways to solve an LP task; the interior-point algorithms are based on determining a feasible solution set to allow finding an optimizer via Newton's method, while the simplex methods take steps along the edges of a polytope, subdividing the set of candidate solutions into simplicial polygons. Interior-point methods stand out among them for their complexity and predictability in terms of convergence properties at the same time. To find the current pattern, we apply five alternative optimization toolboxes: Matlab, MOSEK, Gurobi, SDPT3, and SeDuMi. We suggest that the mutual differences between these vary based on the placement of the target as well as the resolution of the two-parameter lattice. In the numerical experiments, we investigate maximizing the focality and intensity of the L1-L1 optimized stimulation current and, in the latter regard, examine its relationship to the reciprocal current pattern, maximizing the focused current density.

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