论文标题
核酸的力依赖性弹性
Force-dependent elasticity of nucleic acids
论文作者
论文摘要
双链（DS）核酸（NAS）在细胞过程中的功能是由它们的弹性反应强烈介导的。这些过程涉及与dsDNA或dsRNA相互作用并扭曲其结构的蛋白质。大多数理论框架无法正确考虑由这些变形引起的NAS弹性的扰动。在这项工作中，我们介绍了一种新的方法，通过分析双螺旋的波动来评估机械应力对DsDNA和DSRNA弹性响应的影响。这种方法在原子模拟中的应用揭示了dsDNA的力学性能相对于dsRNA的力依赖性的质量差异，我们通过物理上的简约模型与这些分子的结构特征有关。
The functioning of double-stranded (ds) nucleic acids (NAs) in cellular processes is strongly mediated by their elastic response. These processes involve proteins that interact with dsDNA or dsRNA and distort their structures. The perturbation of the elasticity of NAs arising from these deformations is not properly considered by most theoretical frameworks. In this work, we introduce a novel method to assess the impact of mechanical stress on the elastic response of dsDNA and dsRNA through the analysis of the fluctuations of the double helix. Application of this approach to atomistic simulations reveals qualitative differences in the force dependence of the mechanical properties of dsDNA with respect to those of dsRNA, which we relate to structural features of these molecules by means of physically-sound minimalistic models.
