论文标题

线性布尔网络的稳定性

Stability of Linear Boolean Networks

论文作者

Chandrasekhar, Karthik, Kadelka, Claus, Laubenbacher, Reinhard, Murrugarra, David

论文摘要

稳定性是网络模型的重要特征,它对其他理想的方面(例如可控性)具有影响。布尔网络的稳定性取决于各种因素,例如其接线图的拓扑以及描述其动力学的功能的类型。在本文中,我们通过计算德里达曲线并量化其网络拓扑施加的吸引子和周期长度来研究线性布尔网络的稳定性。德里达曲线通常用于测量布尔网络的稳定性和几个参数,例如平均值k,输出偏差P可以指示网络是否稳定,关键或不稳定。对于随机无偏见的布尔网络,存在关键的连接值kc = 2,这样,如果k <kc网络在有序状态下运行,并且如果k> kc网络在混乱的状态下运行。在这里,我们表明,对于最少的口量和最不稳定的线性网络,从订单到混乱的相位过渡已经以kc = 1的平均度内发生。一致地,我们还表明,不稳定的网络表现出大量具有很长的限制周期的吸引子,而稳定和关键的网络的吸引力较少,而限制周期较短。此外,我们提出了理论结果,以量化线性网络的重要动力学特性。首先,我们为线性系统中吸引态的比例提供了一个公式。其次,我们表明线性系统中的固定点的预期数为2,而通用布尔网络平均具有一个固定点。第三,我们提出了一个公式,用于量化射精线性布尔网络的数量,并为此类网络的百分比提供下限。

Stability is an important characteristic of network models that has implications for other desirable aspects such as controllability. The stability of a Boolean network depends on various factors, such as the topology of its wiring diagram and the type of the functions describing its dynamics. In this paper, we study the stability of linear Boolean networks by computing Derrida curves and quantifying the number of attractors and cycle lengths imposed by their network topologies. Derrida curves are commonly used to measure the stability of Boolean networks and several parameters such as the average in-degree K and the output bias p can indicate if a network is stable, critical, or unstable. For random unbiased Boolean networks there is a critical connectivity value Kc=2 such that if K<Kc networks operate in the ordered regime, and if K>Kc networks operate in the chaotic regime. Here, we show that for linear networks, which are the least canalizing and most unstable, the phase transition from order to chaos already happens at an average in-degree of Kc=1. Consistently, we also show that unstable networks exhibit a large number of attractors with very long limit cycles while stable and critical networks exhibit fewer attractors with shorter limit cycles. Additionally, we present theoretical results to quantify important dynamical properties of linear networks. First, we present a formula for the proportion of attractor states in linear systems. Second, we show that the expected number of fixed points in linear systems is 2, while general Boolean networks possess on average one fixed point. Third, we present a formula to quantify the number of bijective linear Boolean networks and provide a lower bound for the percentage of this type of network.

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