论文标题
通过运动蛋白在集体驱动中的合作与竞争：平均有效力，波动和自我载荷
Cooperation and competition in the collective drive by motor proteins: Mean active force, fluctuations, and self-load
论文作者
论文摘要
我们考虑了在运动蛋白的集体驱动器下生物丝的动力学。它们不可逆转地附着在基板上，并与灯丝进行随机附着，以在其上产生定向力。我们使用分析理论和直接数值模拟来建立平均定向力和力相关性对描述单个运动蛋白的参数的依赖性。灯丝运动的有效朗格文描述可提供均值位移，渐近扩散常数和迁移率，导致有效温度。最后，我们展示了运动蛋白扩展之间的竞争如何产生一个自动载荷，可以用有效温度来描述，从而影响细丝运动。
We consider the dynamics of a bio-filament under the collective drive of motor proteins. They are attached irreversibly to a substrate and undergo stochastic attachment-detachment with the filament to produce a directed force on it. We establish the dependence of the mean directed force and force correlations on the parameters describing the individual motor proteins using analytical theory and direct numerical simulations. The effective Langevin description for the filament motion gives mean-squared displacement, asymptotic diffusion constant, and mobility leading to an effective temperature. Finally, we show how competition between motor protein extensions generates a self-load, describable in terms of the effective temperature, affecting the filament motion.
