论文标题
自发皮质活动的共振模型
A Resonance Model for Spontaneous Cortical Activity
论文作者
论文摘要
人类脑功能如何从结构中出现，吸引了研究人员数十年来，并且已经提出了许多模型，但它们都没有产生紧密的结构 - 功能关系。在这里，我们提出了一个基于神经元尖峰时序依赖性可塑性（STDP）原理来描述自发性皮质活动的共振模型，该模型通过将神经元种群之间的动态相互作用纳入波动方程，能够准确地预测静息脑功能连接性（FC），包括静止状态网络。此外，提出的模型提供了强烈的理论和实验证据，即大脑区域之间自发动态耦合以低频的波动。至关重要的是，它能够说明共鸣期间负功能相关性如何出现。我们在时间和频域中释放了人类连接项目（HCP）S1200释放的大量受试者（1038）的模型，这些模型表现出与现有的特征分解模型相比的表现。
How human brain function emerges from structure has intrigued researchers for decades and numerous models have been put forward, yet none of them yields a close structure-function relation. Here we present a resonance model based on neuronal spike timing dependent plasticity (STDP) principle to describe the spontaneous cortical activity by incorporating the dynamic interactions between neuronal populations into a wave equation, which is able to accurately predict the resting brain functional connectivity (FC), including the resting-state networks. Besides, the proposed model provides strong theoretical and experimental evidences that the spontaneous dynamic coupling between brain regions fluctuates with a low frequency. Crucially, it is able to account for how the negative functional correlations emerge during resonance. We test the model with a large cohort of subjects (1038) from the Human Connectome Project (HCP) S1200 release in both time and frequency domain, which exhibits superior performance to existing eigen-decomposition models.
