论文标题
双相情感障碍的老年患者的暴力自杀历史：性别，腹部肥胖和言语记忆的作用：Face-BD队列的结果（双相情感障碍的高级高级专业知识中心）
Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)
论文作者
论文摘要
背景：双相情感障碍（BD）是一种慢性，终身疾病，与肥胖，认知障碍和自杀行为的风险增加有关。腹部肥胖症和较高的暴力自杀企图风险（SA）似乎与年龄，BD和男性相关，直到中年发生与中年相关的女性身体变化发生。这项研究旨在评估腹部肥胖和认知在BD.Methods的剧烈SA负担中的作用：来自定义明确的全国人群face-BD（双极性疾病的高级高级专业知识中心），我们提取了619名在包容型的素质BD患者的数据。进行了横断面临床，认知和代谢评估。 SA历史是基于自我报告的：与非暴力和无SA相反的暴力SA与较高的腰围，腹部肥胖和较差的加利福尼亚语言学习测试短期免费回忆（CVLT-SDFR）（ANOVA，P <.001，p = .014，和P = .006）有关。腰围和腹部肥胖与暴力史与性别，BD类型和焦虑症无关（Exp（b）1.02，CI 1.00-1.05，p = .018; EXP（b）2.16，CI 1.00-4.464，p = .009，相应）。在探索性模型中，腰围和CVLT-SDFR性能介导了男性与暴力SA之间的关联。限制：横断面设计和回顾性报告。结论：暴力SA病史与腹部肥胖症和年龄较大的BD患者的腹部肥胖和较差的言语记忆有关。这些因素是相互联系的，可能会介导男性与暴力SA之间的关联。
Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD.Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report.Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < .001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA.Limitations: Cross-sectional design and retrospective reporting.Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.
