论文标题
肛门运动对食物水解和胃排空的影响：计算模型的见解
Effect of Antral Motility on Food Hydrolysis and Gastric Emptying from the Stomach: Insights from Computational Models
论文作者
论文摘要
胃壁的蠕动运动与酶的分泌结合起来，以启动破坏食物的过程。这种现象的计算建模可以帮助揭示难以通过体内或维特罗手段捕获的细节。在这项研究中，基于成像数据的人烟模型模拟了含有蛋白质的液体粉的消化。胃蛋白酶是用于蛋白质水解的胃酶，从胃壁的近端区域分泌，并允许与胃的含量反应。射流速度，排空速率和水解程度被定量用于对照病例，以及其他三种降低的运动性降低的情况，蠕动幅度的变化。这些发现量化了运动对食物分解和排空速率的影响，并将观察结果与肛门收缩波诱导的胃中的混合相关。
The peristaltic motion of the stomach walls combines with the secretion of enzymes to initiate the process that breaks down food. Computational modelling of this phenomenon can help reveal the details that would be hard to capture via in-vivo or in-vitro means. In this study, the digestion of a liquid meal containing protein is simulated in a human-stomach model based on imaging data. Pepsin, the gastric enzyme for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The jet velocities, the emptying rate, and the extent of hydrolysis are quantified for a control case, and also for three other cases of reduced motility with varying peristaltic amplitudes. The findings quantify the effect of motility on the rate of food breakdown and emptying, and correlate the observations with the mixing in the stomach induced by the antral contraction waves.
