论文标题
阻滞剂对膜通道扩散抗性的影响。对阻滞剂几何形状的依赖
Blocker effect on diffusion resistance of a membrane channel. Dependence on the blocker geometry
论文作者
论文摘要
由于纳米孔感应的最新进展，我们发展了一种大型分析物或阻滞剂的作用的理论，该理论被困在纳米孔范围内，对小溶质的扩散流动。重点是纳米孔扩散抗性，这是纳米孔连接的储层中溶质浓度差与由这种差异驱动的溶质通量的比率。在两个极限情况下，圆柱形纳米孔的轴与圆柱纳米孔的轴重合的圆柱对称阻滞剂的扩散性分析表达式是在阻滞剂半径平稳或突然变化的两个限制情况下与轴的轴相吻合的。我们的理论预测与从布朗动力学模拟获得的结果的比较表明两者之间的良好一致性。
Being motivated by recent progress in nanopore sensing, we develop a theory of the effect of large analytes, or blockers, trapped within the nanopore confines, on diffusion flow of small solutes. The focus is on the nanopore diffusion resistance which is the ratio of the solute concentration difference in the reservoirs connected by the nanopore to the solute flux driven by this difference. Analytical expressions for the diffusion resistance are derived for a cylindrically symmetric blocker whose axis coincides with the axis of a cylindrical nanopore in two limiting cases where the blocker radius changes either smoothly or abruptly. Comparison of our theoretical predictions with the results obtained from Brownian dynamics simulations shows good agreement between the two.
