论文标题
具有动态源区域的系统中模式形成的稳定性
Stability of pattern formation in systems with dynamic source regions
论文作者
论文摘要
我们解释了具有动态建立的源区域的相互作用，可扩散形态的系统中基因表达模式稳定的原理。使用带有阶跃功能生产项的反应扩散模型，我们确定了低精确的不确定图案和形成两个域之间旅行，定义明确的接触区的相之间的相变。我们的模型在分析上解释了单基因域动力学，并为所有可能的两基因调节网络基序提供了模式稳定性条件。
We explain the principles of gene expression pattern stabilization in systems of interacting, diffusible morphogens, with dynamically established source regions. Using a reaction-diffusion model with step-function production term, we identify the phase transition between low-precision indeterminate patterning and the phase in which a traveling, well-defined contact zone between two domains is formed. Our model analytically explains single- and two-gene domain dynamics and provides pattern stability conditions for all possible two-gene regulatory network motifs.
