论文标题
GUILLAIN-BARRE综合征的耦合神经电路设计
A Coupled Neural Circuit Design for Guillain-Barre Syndrome
论文作者
论文摘要
GUILLAIN-BARRE综合征是一种罕见的神经系统疾病,其中人免疫系统会攻击周围神经系统。周围神经系统似乎是神经元模型数学模型的扩散连接系统,并且该系统的周期比每个神经回路的周期都短。传导路径中的刺激将被轴突接收到损失其功能的髓鞘鞘,并在外部传递到靶器官,旨在解决降低神经传导的问题。在神经元模拟环境中,可以创建神经元模型并定义系统内部进行的生物物理事件。在这种环境中,以图形方式获得细胞和树突之间的信号传递。模拟的钾电导和钠电导是足够的,并且电子作用电位与实验测量的电位相当。在这项工作中,我们提出了一个模拟和数字耦合神经元模型,其中包括个人兴奋性和抑制性神经回路块,用于低成本和节能系统。与数字设计相比,我们的模拟设计的性能较低,但能源效率下降了32.3 \%。因此,所得的耦合模拟硬件神经元模型可以是模拟神经传导减少的模型。结果,模拟耦合的神经元(即使具有更大的设计复杂性)是为了使可穿戴的传感器设备开发的严重竞争者,该设备可能有助于Guillain-Barre综合征和其他神经系统疾病。
Guillain-Barre syndrome is a rare neurological condition in which the human immune system attacks the peripheral nervous system. A peripheral nervous system appears as a diffusively connected system of mathematical models of neuron models, and the system's period becomes shorter than the periods of each neural circuit. The stimuli in the conduction path that will address the myelin sheath that has lost its function are received by the axons and are conveyed externally to the target organ, aiming to solve the problem of decreased nerve conduction. In the NEURON simulation environment, one can create a neuron model and define biophysical events that take place within the system for study. In this environment, signal transmission between cells and dendrites is obtained graphically. The simulated potassium and sodium conductance are replicated adequately, and the electronic action potentials are quite comparable to those measured experimentally. In this work, we propose an analog and digital coupled neuron model comprising individual excitatory and inhibitory neural circuit blocks for a low-cost and energy-efficient system. Compared to digital design, our analog design performs in lower frequency but gives a 32.3\% decreased energy efficiency. Thus, the resulting coupled analog hardware neuron model can be a proposed model for the simulation of reduced nerve conduction. As a result, the analog coupled neuron, (even with its greater design complexity) serious contender for the future development of a wearable sensor device that could help with Guillain-Barre syndrome and other neurologic diseases.