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Many discrete optimization problems are amenable to constrained shortest-path reformulations in an extended network space, a technique that has been key in convexification, bound strengthening, and search. In this paper, we propose a constrained variant of these models for two challenging classes of discrete two-stage optimization problems, where traditional methods (e.g., dualize-and-combine) are not applicable compared to their continuous counterparts. Specifically, we propose a framework that models problems as decision diagrams and introduces side constraints either as linear inequalities in the underlying polyhedral representation, or as state variables in shortest-path dynamic programming models. For our first structured class, we investigate two-stage problems with interdiction constraints. We show that such constraints can be formulated as indicator functions in the arcs of the diagram, providing an alternative single-level reformulation of the problem via a network-flow representation. Our second structured class is classical robust optimization, where we leverage the decision diagram network to iteratively identify label variables, akin to an L-shaped method. We evaluate these strategies on a competitive project selection problem and the robust traveling salesperson with time windows, observing considerable improvements in computational efficiency as compared to general methods in the respective areas.