论文标题
用四面体和八面体对称性的分子建模的常见线方法
A common lines approach for ab-initio modeling of molecules with tetrahedral and octahedral symmetry
论文作者
论文摘要
冷冻电子显微镜单个粒子重建的主要任务是在给定一组随机定向和定位的嘈杂投影图像的情况下，找到一个分子的三维模型。在这项工作中，我们提出了一种用于四面体或八面体对称性分子的Ab-Initio重建算法。该算法利用了每个图像中每对投影图像以及自共同线之间的多个共同行。它对输入图像中的噪声非常强大，因为它立即集成了所有图像的信息。使用实验冷冻电子显微镜数据证明了所提出的算法的适用性。
A main task in cryo-electron microscopy single particle reconstruction is to find a three-dimensional model of a molecule given a set of its randomly oriented and positioned noisy projection-images. In this work, we propose an algorithm for ab-initio reconstruction for molecules with tetrahedral or octahedral symmetry. The algorithm exploits the multiple common lines between each pair of projection-images as well as self common lines within each image. It is robust to noise in the input images as it integrates the information from all images at once. The applicability of the proposed algorithm is demonstrated using experimental cryo-electron microscopy data.
