论文标题

基于不完整的纵向和多模态数据的多观察归档和跨意义网络,用于轻度认知障碍的转化预测

Multi-View Imputation and Cross-Attention Network Based on Incomplete Longitudinal and Multimodal Data for Conversion Prediction of Mild Cognitive Impairment

论文作者

Wang, Tao, Chen, Xiumei, Zhang, Xiaoling, Zhou, Shuoling, Feng, Qianjin, Huang, Meiyan

论文摘要

预测患有轻度认知障碍的受试者(MCI)是否将转化为阿尔茨海默氏病是一项重大临床挑战。纵向和多模式数据中固有的纵向变化和互补信息对于MCI转换预测至关重要,但是这些数据中缺少数据的持续问题可能会妨碍其有效的应用。此外,在临床实践的疾病进展的早期,特别是在基线访问(BL)的早期阶段应实现转化预测。因此,仅在训练期间才能合并纵向数据以捕获疾病进展信息。为了应对这些挑战,提出了一个多观看插补和跨意义网络(MCNET),以将数据归档和MCI转换预测整合在统一的框架中。首先,提出了一种与对抗性学习相结合的多观察方法,以处理各种丢失的数据方案并减少归纳错误。其次,引入了两个跨注意区块,以利用纵向和多模式数据中的潜在关联。最后,为数据插补,纵向分类和转换预测任务建立了多任务学习模型。当对模型进行适当培训时,BL数据可以利用从纵向数据中学到的疾病进展信息,以改善BL时MCI转换预测。对MCNET进行了两个独立的测试集和单模式BL数据的测试,以验证其在MCI转换预测中的有效性和灵活性。结果表明,MCNET的表现优于几种竞争方法。此外,已经证明了MCNET的解释性。因此,我们的MCNET可能是MCI转换预测的纵向和多模式数据分析中的有价值工具。代码可在https://github.com/meiyan88/mcnet上找到。

Predicting whether subjects with mild cognitive impairment (MCI) will convert to Alzheimer's disease is a significant clinical challenge. Longitudinal variations and complementary information inherent in longitudinal and multimodal data are crucial for MCI conversion prediction, but persistent issue of missing data in these data may hinder their effective application. Additionally, conversion prediction should be achieved in the early stages of disease progression in clinical practice, specifically at baseline visit (BL). Therefore, longitudinal data should only be incorporated during training to capture disease progression information. To address these challenges, a multi-view imputation and cross-attention network (MCNet) was proposed to integrate data imputation and MCI conversion prediction in a unified framework. First, a multi-view imputation method combined with adversarial learning was presented to handle various missing data scenarios and reduce imputation errors. Second, two cross-attention blocks were introduced to exploit the potential associations in longitudinal and multimodal data. Finally, a multi-task learning model was established for data imputation, longitudinal classification, and conversion prediction tasks. When the model was appropriately trained, the disease progression information learned from longitudinal data can be leveraged by BL data to improve MCI conversion prediction at BL. MCNet was tested on two independent testing sets and single-modal BL data to verify its effectiveness and flexibility in MCI conversion prediction. Results showed that MCNet outperformed several competitive methods. Moreover, the interpretability of MCNet was demonstrated. Thus, our MCNet may be a valuable tool in longitudinal and multimodal data analysis for MCI conversion prediction. Codes are available at https://github.com/Meiyan88/MCNET.

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