论文标题
研究大脑连通性与图形神经网络和gnnexplainer
Investigating Brain Connectivity with Graph Neural Networks and GNNExplainer
论文作者
论文摘要
功能连通性在现代神经科学中起着至关重要的作用。这种方式阐明了大脑的功能和结构方面,包括多种病理背后的机制。一种这样的病理是精神分裂症,通常是听觉口头幻觉。通常通过观察语音处理过程中的功能连接来研究后者。在这项工作中,我们通过对三组人的深度学习进行了对二分法聆听任务期间功能连通性的深入研究:精神分裂症患者有和没有听觉的语言幻觉和健康的对照。我们提出了一个基于图形神经网络的框架,在该框架中我们将脑电图数据表示为图域中的信号。该框架允许一个到1)基于脑电图记录的大脑精神障碍,2)将听力状态与每个组的静止状态区分开,3)识别特征性任务延伸的连接性。实验结果表明,所提出的模型可以区分上述具有最新性能的组。此外,它为研究人员提供了有关每个组功能连接性的有意义的信息,我们在当前领域知识上验证了这一点。
Functional connectivity plays an essential role in modern neuroscience. The modality sheds light on the brain's functional and structural aspects, including mechanisms behind multiple pathologies. One such pathology is schizophrenia which is often followed by auditory verbal hallucinations. The latter is commonly studied by observing functional connectivity during speech processing. In this work, we have made a step toward an in-depth examination of functional connectivity during a dichotic listening task via deep learning for three groups of people: schizophrenia patients with and without auditory verbal hallucinations and healthy controls. We propose a graph neural network-based framework within which we represent EEG data as signals in the graph domain. The framework allows one to 1) predict a brain mental disorder based on EEG recording, 2) differentiate the listening state from the resting state for each group and 3) recognize characteristic task-depending connectivity. Experimental results show that the proposed model can differentiate between the above groups with state-of-the-art performance. Besides, it provides a researcher with meaningful information regarding each group's functional connectivity, which we validated on the current domain knowledge.