论文标题
通过输出系统提高了昼夜节律的精度
Enhanced precision of circadian rhythm by output system
论文作者
论文摘要
昼夜节律是大约24小时的生物节奏，即使在没有环境每日线索的情况下，也持续存在。分子昼夜节律机械产生生理节奏，可以传输到下游输出系统中。由于生化反应的随机性质，单个生物体或细胞表现出的昼夜节律的振荡周期每天都不是恒定的，而在变异系数方面，变化高达10％。尽管昼夜节律中的波动是通过记者（例如生物发光或荧光）测量的，但在实验上证实了记者系统中发现的波动是否与时钟本身相同。这项研究在数值和分析上研究了昼夜节律时钟及其输出系统的耦合系统，然后比较了两个系统的振荡时期的波动。我们发现，当负责输出系统的分子的降解速率的降解速率为典型值时，输出系统中的波动量小于昼夜节律时钟的波动量。获得的结果暗示，输出系统提高了昼夜节律的准确性，而无需任何特殊的降级过程。
Circadian rhythms are biological rhythms of approximately 24 h that persist even under constant conditions without environmental daily cues. The molecular circadian clock machinery generates the physiological rhythms, which can be transmitted into the downstream output system. Owing to the stochastic nature of the biochemical reactions, the oscillation period of circadian rhythms exhibited by individual organisms or cells is not constant on a daily basis with variations as high as 10 % in terms of the coefficient of variation. Although the fluctuations in circadian rhythm is measured through a reporter such as bioluminescence or fluorescence, experimentally confirming whether the fluctuations found in the reporter system are the same as those in the clock itself is challenging. This study numerically and analytically investigated a coupled system of a circadian clock and its output system, and then compared the fluctuations in the oscillation period of the two systems. We found that the amount of fluctuation in the output system is smaller than that in the circadian clock when the degradation rate of the molecules responsible for the output system was at typical values. The results obtained imply that the output system improves the accuracy of the circadian rhythm without the need for any special denoising processes.
