论文标题
细菌DNA中的链内对称性和不对称性：原始基因组的进化特征还是遗物？
Intra-strand symmetries and asymmetries in bacterial DNA: Evolutive features or relics of primordial genomes?
论文作者
论文摘要
在这项工作中，我们分析了一些用于解释细菌基因组中链内平等和链组成不对称的起源的模型。由于这两个特征在细菌DNA中出现了，因此我们从应将其互补现象的角度进行了分析。尽管这些特征的大多数模型都试图解释它们是进化机制的结果，但最近有人提出，它们可能是某些原始基因组的“文物”，这些基因组可以保守地彻底彻底消除基因组进化。我们将要特别注意S-H模型，该模型最长达日期，这是对原始基因组中链内平等和链组成不对称的可能解释的独特模型，这是化学/物理约束下随机性的结果。特别是，我们将讨论测试S-H模型的某些假设的可能方向，我们也将提出S-H模型作为进化模型的可能表述。
In this work we analyze some models used to explain the origins of intra-strand parity and strand compositional asymmetries in bacterial genomes. Due to the particular way that these two features emerge in bacterial DNA, we performed our analysis from the perspective that they are complementary phenomena that should be addressed together. Although most of the models for these features try to explain them as consequence of evolutionary mechanisms, recently it was proposed that they could be `relics' of some primordial genome that were conserved thorough out the genome evolution. We shall pay special attention to the S-H model, which is, up to the date, the unique model proposed as a possible explanation for intra-strand parity and strand compositional asymmetries in primordial genomes as mere consequence of randomness under chemical/physical constraints. In particular, we shall discuss possible directions to test some of the hypotheses of the S-H model, and we will present a possible formulation of the S-H model as an evolutive model too.
