论文标题
肺物理特性对其流动的影响 - 使用肺的详细多尺度数学模型的体积曲线
Influence of lung physical properties on its flow--volume curves using a detailed multi-scale mathematical model of the lung
论文作者
论文摘要
我们开发了肺的数学模型，该模型可以独立估计上支气管中的空气流量和压力。它说明了肺部多尺度特性和空气组织相互作用。使用离散的傅立叶变换来求解模型方程，该变换允许在模型假设的极限下进行准瞬时求解。通过此模型，我们探讨了气流 - 体积曲线如何受气道阻塞或肺合规性变化的影响。我们的工作表明，对流量曲线的精细分析可能会带来有关肺部内部现象的信息。
We develop a mathematical model of the lung that can estimate independently the air flows and pressures in the upper bronchi. It accounts for the lung multi-scale properties and for the air-tissue interactions. The model equations are solved using the Discrete Fourier Transform, which allows quasi instantaneous solving, in the limit of the model hypotheses. With this model, we explore how the air flow--volume curves are affected by airways obstruction or by change in lung compliance. Our work suggests that a fine analysis of the flow-volume curves might bring information about the inner phenomena occurring in the lung.
