学术文献库

We investigate the steady-state fluid--structure interaction between a Newtonian fluid flow and a deformable microtube in two novel geometric configurations arising in recent microfluidics experiments. The first configuration is a cylindrical fluidic channel surrounded by an annulus of soft material with a rigid outer wall, while the second one is a cylindrical fluidic channel extruded from a soft rectangular slab of material. In each configuration, we derive a mathematical theory for the nonlinear flow rate--pressure drop relation by coupling lubrication theory for the flow with linear elasticity for the inner tube wall's deformation. Using the flow conduit's axial slenderness and its axisymmetry, we obtain an analytical expression for the radial displacement in each configuration from a plane-strain configuration. The predicted displacement field, and the resulting closed-form flow rate--pressure drop relation, are each validated against three-dimensional direct numerical simulations via SimVascular's two-way-coupled fluid--structure interaction solver, svFSI, showing good agreement. We also show that weak flow inertia can be easily incorporated in the derivation, further improving the agreement between theory and simulations for larger imposed flow rates.