学术文献库

Estimating the true mortality burden of COVID-19 for every country in the world is a difficult, but crucial, public health endeavor. Attributing deaths, direct or indirect, to COVID-19 is problematic. A more attainable target is the "excess deaths", the number of deaths in a particular period, relative to that expected during "normal times", and we estimate this for all countries on a monthly time scale for 2020 and 2021. The excess mortality requires two numbers, the total deaths and the expected deaths, but the former is unavailable for many countries, and so modeling is required for these countries. The expected deaths are based on historic data and we develop a model for producing expected estimates for all countries and we allow for uncertainty in the modeled expected numbers when calculating the excess. We describe the methods that were developed to produce the World Health Organization (WHO) excess death estimates. To achieve both interpretability and transparency we developed a relatively simple overdispersed Poisson count framework, within which the various data types can be modeled. We use data from countries with national monthly data to build a predictive log-linear regression model with time-varying coefficients for countries without data. For a number of countries, subnational data only are available, and we construct a multinomial model for such data, based on the assumption that the fractions of deaths in sub-regions remain approximately constant over time. Based on our modeling, the point estimate for global excess mortality, over 2020-2021, is 14.9 million, with a 95% credible interval of (13.3, 16.6) million. This leads to a point estimate of the ratio of excess deaths to reported COVID-19 deaths of 2.75, which is a huge discrepancy.