论文标题

大脑建筑:大容器遮挡检测中数据增强的子体积重组

Building Brains: Subvolume Recombination for Data Augmentation in Large Vessel Occlusion Detection

论文作者

Thamm, Florian, Taubmann, Oliver, Jürgens, Markus, Thamm, Aleksandra, Denzinger, Felix, Rist, Leonhard, Ditt, Hendrik, Maier, Andreas

论文摘要

缺血性中风通常是由大容器闭塞(LVO)引起的,可以将其可视化和诊断为计算机断层扫描扫描。由于时间是大脑,因此需要快速,准确和自动化的诊断。人类读者在评估中风时比较了左右半球。基于标准的深度学习模型需要大型培训数据集,以便从数据中学习此策略。由于该领域中标记的医疗数据很少见,因此需要开发其他方法。两者都包括侧面比较的先验知识和增加训练数据的量,我们提出了一种增强方法,该方法通过重新组合半球或半球子区域的血管树分割来生成人工训练样品。该子区域涵盖了通常受LVO影响的血管,即颈内动脉(ICA)和中大脑中动脉(MCA)。与增强方案一致,我们使用带有特定于任务输入的3D-densenet,从而促进了半球之间的并排比较。此外,我们提出了该体系结构的扩展,以处理单个半球子区域。所有配置都可以预测LVO的存在,其侧面和受影响的子区域。我们将重组作为增强策略的效果在5倍的交叉验证研究中。对于所有研究结构的LVO,我们加强了AUC的患者分类。对于一种变体,提出的方法将AUC从0.73提高,而无需增强量增加到0.89。最佳配置可检测LVO的AUC为0.91,ICA中的LVO,AUC为0.96,在MCA中,在MCA中以0.91为0.91,同时准确地预测了受影响的侧。

Ischemic strokes are often caused by large vessel occlusions (LVOs), which can be visualized and diagnosed with Computed Tomography Angiography scans. As time is brain, a fast, accurate and automated diagnosis of these scans is desirable. Human readers compare the left and right hemispheres in their assessment of strokes. A large training data set is required for a standard deep learning-based model to learn this strategy from data. As labeled medical data in this field is rare, other approaches need to be developed. To both include the prior knowledge of side comparison and increase the amount of training data, we propose an augmentation method that generates artificial training samples by recombining vessel tree segmentations of the hemispheres or hemisphere subregions from different patients. The subregions cover vessels commonly affected by LVOs, namely the internal carotid artery (ICA) and middle cerebral artery (MCA). In line with the augmentation scheme, we use a 3D-DenseNet fed with task-specific input, fostering a side-by-side comparison between the hemispheres. Furthermore, we propose an extension of that architecture to process the individual hemisphere subregions. All configurations predict the presence of an LVO, its side, and the affected subregion. We show the effect of recombination as an augmentation strategy in a 5-fold cross validated ablation study. We enhanced the AUC for patient-wise classification regarding the presence of an LVO of all investigated architectures. For one variant, the proposed method improved the AUC from 0.73 without augmentation to 0.89. The best configuration detects LVOs with an AUC of 0.91, LVOs in the ICA with an AUC of 0.96, and in the MCA with 0.91 while accurately predicting the affected side.

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