论文标题
肿瘤微环境中肿瘤免疫空间关系表征的新型框架
A Novel Framework for Characterization of Tumor-Immune Spatial Relationships in Tumor Microenvironment
论文作者
论文摘要
了解肿瘤生物学对附近细胞组成的影响通常需要表征生物学上不同肿瘤区域的影响。已经开发出生物标志物来标记生物学上不同的肿瘤区域，但由于空间范围和差异标记区域的分布而存在差异，因此出现了挑战。在这项工作中，我们提出了一个框架，用于系统地研究不同肿瘤区域对肿瘤边界附近细胞的影响，从而考虑了它们的跨空间分布。我们将框架应用于胰腺癌的多重免疫组织化学（MIHC）研究，并显示出其在证明生物学上不同的肿瘤区域如何影响肿瘤微环境中免疫反应的功效。此外，我们表明所提出的框架可以扩展到全幻灯片图像分析。
Understanding the impact of tumor biology on the composition of nearby cells often requires characterizing the impact of biologically distinct tumor regions. Biomarkers have been developed to label biologically distinct tumor regions, but challenges arise because of differences in the spatial extent and distribution of differentially labeled regions. In this work, we present a framework for systematically investigating the impact of distinct tumor regions on cells near the tumor borders, accounting their cross spatial distributions. We apply the framework to multiplex immunohistochemistry (mIHC) studies of pancreatic cancer and show its efficacy in demonstrating how biologically different tumor regions impact the immune response in the tumor microenvironment. Furthermore, we show that the proposed framework can be extended to largescale whole slide image analysis.
