论文标题

联合学习,用于分类肿瘤浸润淋巴细胞

Federated Learning for the Classification of Tumor Infiltrating Lymphocytes

论文作者

Baid, Ujjwal, Pati, Sarthak, Kurc, Tahsin M., Gupta, Rajarsi, Bremer, Erich, Abousamra, Shahira, Thakur, Siddhesh P., Saltz, Joel H., Bakas, Spyridon

论文摘要

我们评估了联合学习(FL)在开发深度学习模型以分析数字化组织切片中的表现。分类应用被认为是示例用例,以量化整个幻灯片图像(WSIS)中肿瘤浸润淋巴细胞的分布。使用从WSIS提取的50*50平方微米斑块训练了深度学习分类模型。我们模拟了一个FL环境,在该环境中,通过癌症基因组图集存储库可用的许多解剖部位生成的癌症生成的数据集分为8个不同的节点。我们的研究结果表明,接受联合培训方法训练的模型在定量和定性上都达到了相似的性能,该模型与在集中位置汇集的所有培训数据训练的模型的模型。我们的研究表明,FL具有巨大的潜力,可以为组织病理学图像分析开发更健壮和准确的模型,而无需在一个位置收集大型和多样化的培训数据。

We evaluate the performance of federated learning (FL) in developing deep learning models for analysis of digitized tissue sections. A classification application was considered as the example use case, on quantifiying the distribution of tumor infiltrating lymphocytes within whole slide images (WSIs). A deep learning classification model was trained using 50*50 square micron patches extracted from the WSIs. We simulated a FL environment in which a dataset, generated from WSIs of cancer from numerous anatomical sites available by The Cancer Genome Atlas repository, is partitioned in 8 different nodes. Our results show that the model trained with the federated training approach achieves similar performance, both quantitatively and qualitatively, to that of a model trained with all the training data pooled at a centralized location. Our study shows that FL has tremendous potential for enabling development of more robust and accurate models for histopathology image analysis without having to collect large and diverse training data at a single location.

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