论文标题
神经胶质瘤入侵和治疗方法的数学模型通过活性颗粒的动力学理论
Mathematical modeling of glioma invasion and therapy approaches via kinetic theory of active particles
论文作者
论文摘要
在血管性和血管内皮生长因子的影响下，胶质瘤的多尺度模型在脑组织中扩散。它说明了肿瘤的不同成分与健康组织之间的相互作用，并研究和比较了各种治疗方法。确切地说，这些涉及以并发或辅助方式以及影响系统血管成分的抗血管生成疗法的放射和化学疗法。我们根据DTI数据评估肿瘤的生长并扩散，这使我们能够重建逼真的脑几何形状和组织结构，并将模型应用于实际神经胶质瘤患者数据。在后一种情况下，使用有关相应异源曲线的数据考虑了依赖空间的放射疗法描述。
A multiscale model for glioma spread in brain tissue under the influence of vascularization and vascular endothelial growth factors is proposed. It accounts for the interplay between the different components of the neoplasm and the healthy tissue and it investigates and compares various therapy approaches. Precisely, these involve radio- and chemotherapy in a concurrent or adjuvant manner together with anti-angiogenic therapy affecting the vascular component of the system. We assess tumor growth and spread on the basis of DTI data, which allows us to reconstruct a realistic brain geometry and tissue structure, and we apply our model to real glioma patient data. In this latter case, a space-dependent radiotherapy description is considered using data about the corresponding isodose curves.
