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This paper proposes an approach to improve Non-Intrusive speech quality assessment(NI-SQA) based on the residuals between impaired speech and enhanced speech. The difficulty in our task is particularly lack of information, for which the corresponding reference speech is absent. We generate an enhanced speech on the impaired speech to compensate for the absence of the reference audio, then pair the information of residuals with the impaired speech. Compared to feeding the impaired speech directly into the model, residuals could bring some extra helpful information from the contrast in enhancement. The human ear is sensitive to certain noises but different to deep learning model. Causing the Mean Opinion Score(MOS) the model predicted is not enough to fit our subjective sensitive well and causes deviation. These residuals have a close relationship to reference speech and then improve the ability of the deep learning models to predict MOS. During the training phase, experimental results demonstrate that paired with residuals can quickly obtain better evaluation indicators under the same conditions. Furthermore, our final results improved 31.3 percent and 14.1 percent, respectively, in PLCC and RMSE.