论文标题
感知特征作为帕金森氏病的标志：临床解释性问题
Perceptual Features as Markers of Parkinson's Disease: The Issue of Clinical Interpretability
论文作者
论文摘要
多达90％的帕金森氏病（PD）患者患有迟发性乳头虫（HD），这在发声领域也表现出来。 HD的临床迹象，例如Monoloudness，Monopitch或嘶哑的声音，通常通过常规的临床可解释特征（抖动，微光，谐波与噪声比例等）来量化。 This paper provides large and robust insight into perceptual analysis of 5 Czech vowels of 84 PD patients and proves that despite the clinical inexplicability the perceptual features outperform the conventional ones, especially in terms of discrimination power (classification accuracy ACC = 92 %, sensitivity SEN = 93 %, specificity SPE = 92 %) and partial correlation with clinical scores like UPDRS (Unified Parkinson's disease rating比例尺），MMSE（小精神状态检查）或雾（步态问卷的冻结），其中p <0.0001。
Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) which is also manifested in the field of phonation. Clinical signs of HD like monoloudness, monopitch or hoarse voice are usually quantified by conventional clinical interpretable features (jitter, shimmer, harmonic-to-noise ratio, etc.). This paper provides large and robust insight into perceptual analysis of 5 Czech vowels of 84 PD patients and proves that despite the clinical inexplicability the perceptual features outperform the conventional ones, especially in terms of discrimination power (classification accuracy ACC = 92 %, sensitivity SEN = 93 %, specificity SPE = 92 %) and partial correlation with clinical scores like UPDRS (Unified Parkinson's disease rating scale), MMSE (Mini-mental state examination) or FOG (Freezing of gait questionnaire), where p < 0.0001.
