学术文献库

Assigning accurate conductivity values in human head models is an essential factor for performing precise electroencephalographic (EEG) source localization and targeting of transcranial electrical stimulation (TES). Unfortunately, the literature reports diverging conductivity values of the different tissues in the human head. The current study analyzes first the performance of in-vivo conductivity estimation for different configurations concerning the localization of the electrical source and measurement. Then, it presents conductivity estimates for three epileptic patients using scalp EEG and intracerebral stereotactic EEG (sEEG) acquired in simultaneous with intracerebral electrical stimulation. The estimates of the conductivities were based on finite-element models of the human head with five tissue compartments of homogeneous and isotropic conductivities. The results of this study show that in-vivo conductivity estimation can lead to different estimated conductivities for the same patient when considering different stimulation positions, different measurement positions or different measurement modalities (sEEG or EEG). This work provides important guidelines to in-vivo conductivity estimation and explains the variability among the conductivity values which have been reported in previous studies.