论文标题
贪婪优化电气线虫假体的电极布置
Greedy Optimization of Electrode Arrangement for Epiretinal Prostheses
论文作者
论文摘要
视觉神经假体是唯一用于治疗视网膜退行性失明的技术。尽管最近的工作表明电极位置与引起的视觉感知的形状之间存在系统关系，但这些知识尚未纳入视网膜假体设计中，其中电极通常在矩形或六角形网格上排列。在这里，我们使用词典学习优化了眼前电极的眼内放置。重要的是，优化过程是由先前建立的和心理物理验证的模拟假体视力模型所告知的。我们系统地评估了各种可能的磷酸形状的三种不同的电极放置策略，并建议电极布置最大化视觉子场覆盖率。在不久的将来，我们的工作可能指导下一代神经植物的原型制作。
Visual neuroprostheses are the only FDA-approved technology for the treatment of retinal degenerative blindness. Although recent work has demonstrated a systematic relationship between electrode location and the shape of the elicited visual percept, this knowledge has yet to be incorporated into retinal prosthesis design, where electrodes are typically arranged on either a rectangular or hexagonal grid. Here we optimize the intraocular placement of epiretinal electrodes using dictionary learning. Importantly, the optimization process is informed by a previously established and psychophysically validated model of simulated prosthetic vision. We systematically evaluate three different electrode placement strategies across a wide range of possible phosphene shapes and recommend electrode arrangements that maximize visual subfield coverage. In the near future, our work may guide the prototyping of next-generation neuroprostheses.
