论文标题
壳壳中DNA分子的结构分析
Structural Analysis of DNA molecule in a confined shell
论文作者
论文摘要
在DNA研究的许多领域，尤其是基因治疗方面，操作和操纵DNA的最新进展为许多领域提供了独特的实验可能性。研究人员已经部署了许多实验和理论技术，以研究由于外部扰动而导致的DNA结构变化。了解在限制状态下DNA分子的结构和动态变化至关重要，以理解和控制限制在腔室或纳米通道中的DNA的自组装。在当前的手稿中，我们扩展了工作研究对限制对热稳定性和双工DNA的结构特性的影响。目前的工作是我们以前的研究工作的扩展。对于我们的研究，我们考虑了一个限制在圆柱几何形状中的1 BNA链。限制的几何形状如何影响DNA分子的开口和其他结构参数是该手稿的目的。我们为我们的目的使用了统计模型（PBD模型）和分子动力学模拟。
Recent advances in operating and manipulating DNA have provided unique experimental possibilities in many fields of DNA research, especially in gene therapy. Researchers have deployed many techniques, experimental and theoretical, to study the DNA structure changes due to external perturbation. It is crucial to understand the structural and dynamical changes in the DNA molecules in a confined state to understand and control the self-assembly of DNA confined in a chamber or nano-channel for various applications. In the current manuscript, we extend the work study the effect of confinement on the thermal stability and the structural properties of duplex DNA. The present work is an extension of our previous research works. For our study we have considered a 1 BNA chain that is confined in a cylindrical geometry. How the geometry of the confinement affects the opening and other structural parameters of DNA molecule is the objective of this manuscript. We have used a statistical model(PBD model) and Molecular dynamics simulations for our purpose.
