论文标题
使用3D打印的拟人化头部和颈部幻影的蒙特卡洛碘131放射性药物测量工作流
Validation of Monte Carlo Iodine-131 radiopharmaceutical dosimetry workflow using a 3D printed anthropomorphic head and neck phantom
论文作者
论文摘要
目的：在这项研究中，我们介绍了拟人化，头颈，核医学幻影的创建及其在验证蒙特卡洛，基于SPECT图像的iodine-131 RPT剂量剂量剂量工作流程的表征。 方法：3D打印技术用于从患者CT数据集中创建拟人化幻影。使用均匀的Jaszczak和拟人化幻影进行了三项碘-131 SPECT/CT成像研究，以量化SPECT图像。使用基于图像的Geant4 Monte Carlo RPT剂量学工作流程计算了准直仪检测器响应（CDR）建模和基于体积的部分体积校正（PVC）对吸收剂量的影响，并与地面真实情况进行了比较。最后，根据最近的EANM指南对不确定性进行了量化。 结果：3D打印的拟人化幻影是对包括骨骼在内的患者解剖结构的准确重新创建。对于CDR和非CDR病例，推断的Jaszczak恢复系数大于3D打印插入物（〜22.8 mL）的系数。利用Jaszczak Phantom PVCS，吸收的剂量分别被低估了0.7％和4.9％，没有CDR和CDR。利用有或没有CDR的拟人化幻影RC将吸收的剂量降低了3％。掺入PVC的所有剂量法场景都属于活动的不确定性。 Jaszczak球的累积活性的不确定性在25.6％至113％之间，体积从0.5 mL到16毫升。 结论：用拟人化幻影验证了头颈癌中蒙特卡洛剂量法对头颈癌中碘的准确性。幻影的未来应用可能涉及3D打印和表征患者特定量的特定量，以获得更个性化的RPT剂量测定估计。
Purpose: In this study, we present the creation of an anthropomorphic, head and neck, nuclear medicine phantom and its characterization for the validation of a Monte Carlo, SPECT image based, Iodine-131 RPT dosimetry workflow. Methods: 3D printing techniques were used to create the anthropomorphic phantom from a patient CT dataset. Three Iodine-131 SPECT/CT imaging studies were performed using a homogeneous, Jaszczak, and an anthropomorphic phantom to quantify the SPECT images. The impact of collimator detector response (CDR) modeling and volume-based partial volume corrections (PVC) upon the absorbed dose was calculated using an image based, Geant4 Monte Carlo RPT dosimetry workflow and compared against a ground truth scenario. Finally, uncertainties were quantified in accordance with recent EANM guidelines. Results: The 3D printed anthropomorphic phantom was an accurate re-creation of patient anatomy including bone. The extrapolated Jaszczak recovery coefficients were greater than that of the 3D printed insert (~22.8 ml) for both the CDR and non-CDR cases. Utilizing Jaszczak phantom PVCs, the absorbed dose was underpredicted by 0.7% and 4.9% without and with CDR, respectively. Utilizing anthropomorphic phantom RCs overpredicted the absorbed dose by 3% both with and without CDR. All dosimetry scenarios that incorporated PVC were within the calculated uncertainty of the activity. The uncertainties in the cumulative activity ranged from 25.6% to 113% for Jaszczak spheres ranging in volume from 0.5 ml to 16 ml. Conclusion: The accuracy of Monte Carlo-based dosimetry for Iodine-131 RPT in head and neck cancer was validated with an anthropomorphic phantom. Future applications of the phantom could involve 3D printing and characterizing patient specific volumes for more personalized RPT dosimetry estimates.
