论文标题
将人口历史纳入不同人群的遗传研究的机遇和挑战：夏威夷原住民的激励人物
The opportunities and challenges of integrating population histories into genetic studies of diverse populations: a motivating example from Native Hawaiians
论文作者
论文摘要
紧急且众所周知的需要将遗传学研究扩展到各种人群，但是几个障碍仍然是令人难以置信的，包括（但不限于）招募大量人群中的个体的困难，并且缺乏可用基因组参考的代表性。尽管存在这些障碍，研究多种多样的人群将提供信息丰富的特定人群见解。我将以独特的进化史的夏威夷人为例，以开发关键的基因组资源并将进化思维整合到遗传流行病学中，我们将有机会有效地促进对遗传危险因素的了解，增强健康差异的知识，并改善这种不受欢迎的人群的医疗保健。
There is an urgent and well-recognized need to extend genetic studies to diverse populations, but several obstacles continue to be prohibitive, including (but not limited to) the difficulty of recruiting individuals from diverse populations in large numbers and the lack of representation in available genomic references. These obstacles notwithstanding, studying multiple diverse populations would provide informative, population-specific insights. Using Native Hawaiians as an example of an understudied population with a unique evolutionary history, I will argue that by developing key genomic resources and integrating evolutionary thinking into genetic epidemiology, we will have the opportunity to efficiently advance our knowledge of the genetic risk factors, ameliorate health disparity, and improve healthcare in this underserved population.
