论文标题
剪切速率和表面化学对微观分支中血栓形成的影响
Influence of shear rate and surface chemistry on thrombus formation in micro-crevice
论文作者
论文摘要
在机械循环支持方面，血栓栓塞并发症仍然是患者管理的核心问题。尽管在现代心室辅助设备设计和制造中采用了最佳实践，但这些系统的复杂性和模块化性质通常会在流动路径中引入内部步骤和缝隙，这些步骤和缝隙可以用作血栓形成的Nidus。血小板电位受生物材料的流量和表面化学特征在内的多种因素的影响。这项研究使用多个基于血栓形成的数值模型探索了这些元素在微观经验上的血流中探索了这些元素。模拟重现了实验观察到的血小板沉积模式，并阐明了流动，剪切速率和表面化学在塑造沉积中的作用。结果提供了有关血液接触设备的设计和操作的见解。
Thromboembolic complications remain a central issue in management of patients on mechanical circulatory support. Despite the best practices employed in design and manufacturing of modern ventricular assist devices, complexity and modular nature of these systems often introduces internal steps and crevices in the flow path which can serve as nidus for thrombus formation. Thrombotic potential is influenced by multiple factors including the characteristics of the flow and surface chemistry of the biomaterial. This study explored these elements in the setting of blood flow over a micro-crevice using a multi-constituent numerical model of thrombosis. The simulations reproduced the platelet deposition patterns observed experimentally and elucidated the role of flow, shear rate, and surface chemistry in shaping the deposition. The results offer insights for design and operation of blood-contacting devices.
