论文标题
伪造盲检查检测凝胶电泳图像的操纵
Forgery Blind Inspection for Detecting Manipulations of Gel Electrophoresis Images
论文作者
论文摘要
最近，在研究不当行为的论文中发现了伪造的图像。然而，尽管有许多图像伪造的检测方法，但它们都不是为分子生物实验图像而设计的。在本文中，我们提出了一种名为FBI $ _ {gel} $的快速盲目询问方法，以从两种常见的分子实验中获得的图像的完整性，即蛋白质印迹（WB）和聚合酶链反应（PCR）。 FBI $ _ {gel} $基于能够突出局部残留物的优化伪背景，可以揭示可追溯的痕迹，暗示WB/PCR图像上不适当的局部修改。此外，由于优化的伪背景是根据封闭形式的解决方案得出的，因此FBI $ _ {gel} $在计算上是有效的，因此适用于WB/PCR图像完整性的大型查询任务。我们在公众对\ textbf {pubpeer}质疑的几篇论文上应用了FBI $ _ {gel} $，我们的结果表明，这些论文的数字确实包含了可疑的不自然模式。
Recently, falsified images have been found in papers involved in research misconducts. However, although there have been many image forgery detection methods, none of them was designed for molecular-biological experiment images. In this paper, we proposed a fast blind inquiry method, named FBI$_{GEL}$, for integrity of images obtained from two common sorts of molecular experiments, i.e., western blot (WB) and polymerase chain reaction (PCR). Based on an optimized pseudo-background capable of highlighting local residues, FBI$_{GEL}$ can reveal traceable vestiges suggesting inappropriate local modifications on WB/PCR images. Additionally, because the optimized pseudo-background is derived according to a closed-form solution, FBI$_{GEL}$ is computationally efficient and thus suitable for large scale inquiry tasks for WB/PCR image integrity. We applied FBI$_{GEL}$ on several papers questioned by the public on \textbf{PUBPEER}, and our results show that figures of those papers indeed contain doubtful unnatural patterns.
