论文标题
经颅双极直流电流的额叶皮层刺激降低了氯胺酮诱导的振荡：镇静大鼠的试验研究
Transcranial Bipolar Direct Current Stimulation of the Frontoparietal Cortex Reduces Ketamine-Induced Oscillopathies: A Pilot Study in the Sedated Rat
论文作者
论文摘要
跑步标题：额心阳极TDCS减少氯胺酮引起的振荡性。提取物：在精神分裂症的前驱阶段，其复杂而阴险的临床图片，脑电图记录可检测到广泛的振荡障碍（或示波器病）。神经振荡是系统内连接状态的电标志。氯胺酮是一种非竞争力的NMDA谷氨酸受体拮抗剂的单一全身性给药，通过临床图片使人联想到精神病前期，从而瞬时再现了振荡性。这种急性药理模型可以帮助研究和开发针对精神病过渡的创新治疗方法。经颅电刺激被认为是一种适当的非侵入性治疗方式，因为它可以增加认知性能并调节几乎没有或没有副作用的神经振荡。因此，我们的目标是在镇静的成年大鼠中建立一种刺激方法，能够使氯胺酮诱导的振动病正常化。通过直流电流（<+1 mA）刺激单方面经颅额叶阳极刺激在氯胺酮治疗的大鼠中。顶叶皮层的伴随脑电图记录测量了刺激对其自发性振荡的影响。一个5分钟的双极阳极TDC立即并迅速降低，显着降低了强度效应的关系，至少在双侧顶叶皮层中，氯胺酮诱导的振荡性。还记录了持续时间。这些初步的神经生理学发现有望建立针对神经精神疾病的治疗概念证明。
Running title: Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies.Abstract: During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies). Neural oscillations are electro-biomarkers of the connectivity state within systems. A single systemic administration of ketamine, a non-competitive NMDA glutamate receptor antagonist, transiently reproduces the oscillopathies with a clinical picture reminiscent of the psychosis prodrome. This acute pharmacological model may help the research and development of innovative treatments against the psychotic transition. Transcranial electrical stimulation is recognized as an appropriate non-invasive therapeutic modality since it can increase cognitive performance and modulate neural oscillations with little or no side effects. Therefore, our objective was to set up, in the sedated adult rat, a stimulation method able to normalize the ketamine-induced oscillopathies. Unilateral transcranial frontoparietal anodal stimulation by direct current (<+1 mA) was applied in ketamine-treated rats. A concomitant electroencephalographic recording of the parietal cortex measured the stimulation effects on its spontaneously-occurring oscillations. A 5-min bipolar anodal tDCS immediately and quickly reduced, significantly with an intensity-effect relationship, the ketamine-induced oscillopathies at least in the bilateral parietal cortex. A duration effect was also recorded. These preliminary neurophysiological findings are promising for developing a therapeutic proof-of-concept against neuropsychiatric disorders.
