论文标题
建模线索 - 核兼容性及其在物种识别中的作用
Modeling Mito-nuclear Compatibility and its Role in Species Identification
论文作者
论文摘要
线粒体遗传物质被广泛用于系统发育重建和物种鉴定条形码。在这里，我们研究线索核相互作用如何影响mtDNA鉴定物种的准确性以及物种过程本身。我们模拟了携带重组核基因组和线粒体基因组的个体人群的演变。我们比较了一个无线核互动与相互作用影响适应性的情况，该模型的适应性景观与缺乏任何线核相互作用。适应性是根据个人的线粒体核兼容性分配给个体的，这驱动了核和线粒体基因组的共同进化。当种群分解为不同的物种时，我们分析了mtDNA条形码在物种鉴定中的准确性。值得注意的是，我们发现在存在或不存在线粒体 - 核耦合的情况下，mtDNA的物种鉴定同样准确，并且DNA条形码的成功主要源于物种物种期间种群的地理分离。然而，通过Mito-核兼容性进行的选择会影响多样化的过程，并以三种方式在遗传含量和人群的空间分布中留下特征：系统发育树更加平衡；进化枝与空间分布密切相关；种子内mtDNA相似性有很大的增加。我们将模型中观察到的进化模式与来自copepods的经验数据进行了比较（\ textit {t。Californicus}）。我们发现在地理模式和系统发育树的拓扑中的良好定性一致性，前提是该模型包括基于Mito核相互作用的选择。这些结果突出了线索 - 核兼容性在物种过程中的作用及其从遗传数据中重建的作用。
Mitochondrial genetic material is widely used for phylogenetic reconstruction and as a barcode for species identification. Here we study how mito-nuclear interactions affect the accuracy of species identification by mtDNA, as well as the speciation process itself. We simulate the evolution of a population of individuals who carry a recombining nuclear genome and a mitochondrial genome inherited maternally. We compare a null model fitness landscape that lacks any mito-nuclear interaction against a scenario in which interactions influence fitness. Fitness is assigned to individuals according to their mito-nuclear compatibility, which drives the coevolution of the nuclear and mitochondrial genomes. When the population breaks into distinct species we analyze the accuracy of mtDNA barcode for species identification. Remarkably, we find that species identification by mtDNA is equally accurate in the presence or absence of mito-nuclear coupling and that the success of the DNA barcode derives mainly from population geographical isolation during speciation. Nevertheless, selection imposed by mito-nuclear compatibility influences the diversification process and leaves signatures in the genetic content and spatial distribution of the populations, in three ways: phylogenetic trees are more balanced; clades correlate strongly with the spatial distribution and; there is a substantial increase in the intraspecies mtDNA similarity. We compare the evolutionary patterns observed in our model to empirical data from copepods (\textit{T. californicus}). We find good qualitative agreement in the geographic patterns and the topology of the phylogenetic tree, provided the model includes selection based on mito-nuclear interactions. These results highlight the role of mito-nuclear compatibility in the speciation process and its reconstruction from genetic data.
