论文标题
非人类灵长类动物MRI的最小规格:标准化和协调数据收集的挑战
Minimal Specifications for Non-Human Primate MRI: Challenges in Standardizing and Harmonizing Data Collection
论文作者
论文摘要
MRI的最新方法学进步使非人类灵长类动物(NHP)的神经影像学研究实现了实质性增长,而通过Prime-DE倡议进行开放数据共享增强了NHP MRI数据的可用性,并且需要强大的多主体多中心分析。简化的采集和分析协议将加速并改善这些努力。但是,关于数据采集方案的最小标准和NHP成像分析管道的共识尚待建立,特别是对于多中心研究。在这里,我们在NHP和人类神经影像学之间划出了相似之处,并提供了协调和标准化数据获取的最低指南。我们提倡对广泛使用的开放式工具包的强大翻译,这些工具包已建立了用于分析人类数据的良好的转换。我们还鼓励使用经过验证的自动化预处理工具来分析NHP数据集。这些指南旨在完善小规模和大规模NHP神经影像数据的方法论和分析策略。这将提高结果的可重复性,并加快NHP与人类神经影像学策略之间的收敛性,这些策略最终将使基本和转化的脑科学受益。
Recent methodological advances in MRI have enabled substantial growth in neuroimaging studies of non-human primates (NHPs), while open data-sharing through the PRIME-DE initiative has increased the availability of NHP MRI data and the need for robust multi-subject multi-center analyses. Streamlined acquisition and analysis protocols would accelerate and improve these efforts. However, consensus on minimal standards for data acquisition protocols and analysis pipelines for NHP imaging remains to be established, particularly for multi-center studies. Here, we draw parallels between NHP and human neuroimaging and provide minimal guidelines for harmonizing and standardizing data acquisition. We advocate robust translation of widely used open-access toolkits that are well established for analyzing human data. We also encourage the use of validated, automated pre-processing tools for analyzing NHP data sets. These guidelines aim to refine methodological and analytical strategies for small and large-scale NHP neuroimaging data. This will improve reproducibility of results, and accelerate the convergence between NHP and human neuroimaging strategies which will ultimately benefit fundamental and translational brain science.