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BACKGROUND AND OBJECTIVE: The research done in the field of Augmented Reality (AR) for patient positioning in radiation therapy is scarce. We propose an efficient and cost-effective algorithm for tracking the scene and the patient to interactively assist the patient's positioning process by providing visual feedback to the operator. Up to our knowledge, this is the first framework that can be employed for mobile interactive AR to guide patient positioning. METHODS: We propose a point cloud processing method that combined with a fiducial marker-mapper algorithm and the generalized ICP algorithm tracks the patient and the camera precisely and efficiently only using the CPU unit. The alignment between the 3D reference model and body marker map is calculated employing an efficient body reconstruction algorithm. RESULTS: Our quantitative evaluation shows that the proposed method achieves a translational and rotational error of 4.17 mm/0.82 deg at 9 fps. Furthermore, the qualitative results demonstrate the usefulness of our algorithm in patient positioning on different human subjects. CONCLUSION: Since our algorithm achieves a relatively high frame rate and accuracy employing a regular laptop (without the usage of a dedicated GPU), it is a very cost-effective AR-based patient positioning method. It also opens the way for other researchers by introducing a framework that could be improved upon for better mobile interactive AR patient positioning solutions in the future.