论文标题
基于水凝胶的生物纳米机械发射机，用于细菌分子通信
Hydrogel-based Bio-nanomachine Transmitters for Bacterial Molecular Communications
论文作者
论文摘要
细菌法定人数可以根据其内在作用作为交流手段来设计生物技术应用的设计。我们提出了一个正反馈回路的创建，该反馈将从细菌种群中促进超折叠绿色荧光蛋白的发射，该蛋白将流过水凝胶，该蛋白质用于封装细胞。这些工程的细胞源自被称为生物纳米机械发射机，我们表明，对于较低的扩散系数值，可以产生较高的分子输出信号功率，这支持用于分子通信系统中水凝胶中包含的工程细菌的使用。此外，我们的湿实验室结果显示了分子输出信号的传播，证明了工程为正反馈回路的可行性，以创建可用于生物传感应用的生物纳米机械发射器。
Bacterial quorum sensing can be engineered with a view to the design of biotechnological applications based on their intrinsic role as a means of communication. We propose the creation of a positive feedback loop that will promote the emission of a superfolded green fluorescence protein from a bacterial population that will flow through hydrogel, which is used to encapsulate the cells. These engineered cells are heretofore referred to as bio-nanomachine transmitters and we show that for lower values of diffusion coefficient, a higher molecular output signal power can be produced, which supports the use of engineered bacteria contained within hydrogels for molecular communications systems. In addition, our wet lab results show the propagation of the molecular output signal, proving the feasibility of engineering a positive feedback loop to create a bio-nanomachine transmitter that can be used for biosensing applications.
