论文标题
翻译的健身景观
The fitness landscapes of translation
论文作者
论文摘要
在最近关于抗生素抗性基因的实验的动机中，我们研究了在翻译模型排除模型的框架中的同义突变之间的遗传相互作用。我们表明，可能的相互作用范围明显不同，具体取决于假定翻译效率与核糖体电流或核糖体速度成正比。在第一种情况下，每个突变效应都具有明确的符号，该符号独立于遗传背景，而在第二种情况下，效应 - 符号可以根据其他突变的存在而变化。使用慢速密码子引起的多个翻译瓶颈的配置证明了后一个结果。
Motivated by recent experiments on an antibiotic resistance gene, we investigate genetic interactions between synonymous mutations in the framework of exclusion models of translation. We show that the range of possible interactions is markedly different depending on whether translation efficiency is assumed to be proportional to ribosome current or ribosome speed. In the first case every mutational effect has a definite sign that is independent of genetic background, whereas in the second case the effect-sign can vary depending on the presence of other mutations. The latter result is demonstrated using configurations of multiple translational bottlenecks induced by slow codons.
