论文标题
基于磁共振成像的血管异质性评估的无监督学习：血液动力组织特征
Unsupervised learning for vascular heterogeneity assessment of glioblastoma based on magnetic resonance imaging: The Hemodynamic Tissue Signature
论文作者
论文摘要
本论文的重点是血液动力学组织特征（HTS）方法的研究和开发：一种无监督的机器学习方法，通过灌注MRI分析来描述胶质母细胞瘤的血管异质性。 HTS建立在栖息地的概念上。栖息地定义为病变的子区域，其特定的MRI谱描述了特定的生理行为。 HTS方法将胶质母细胞瘤中的四个栖息地描述为：高血管生成肿瘤（HAT）栖息地，是增强肿瘤中最灌注的区域；低血管生成肿瘤（LAT）栖息地，作为具有较低血管生成特征的增强肿瘤区域；潜在的浸润的外围水肿（IPE）栖息地为与肿瘤较高的肿瘤相邻的非增强区域。以及血管生成外周水肿（VPE）栖息地，作为灌注最低的病变的剩余水肿。 本文的结果已在十项科学贡献中发表，包括在医学信息学，统计和概率，放射学和核医学，机器学习以及数据挖掘以及生物医学工程领域的排名最高的期刊和会议。还发布了一项在西班牙（ES201431289A），欧洲（EP3190542A1）和EEUU（US20170287133A1）注册的工业专利，总结了论文为从研究出版物获得的学术收入而产生有形资产的努力。最后，在本文中构思的方法，技术和原始思想导致了Oncoanalytics CDX的基础，该公司构建了药品化合物的伴侣诊断商业模型，认为是促进OnCohabitats技术工业化的工具。
This thesis focuses on the research and development of the Hemodynamic Tissue Signature (HTS) method: an unsupervised machine learning approach to describe the vascular heterogeneity of glioblastomas by means of perfusion MRI analysis. The HTS builds on the concept of habitats. An habitat is defined as a sub-region of the lesion with a particular MRI profile describing a specific physiological behavior. The HTS method delineates four habitats within the glioblastoma: the High Angiogenic Tumor (HAT) habitat, as the most perfused region of the enhancing tumor; the Low Angiogenic Tumor (LAT) habitat, as the region of the enhancing tumor with a lower angiogenic profile; the potentially Infiltrated Peripheral Edema (IPE) habitat, as the non-enhancing region adjacent to the tumor with elevated perfusion indexes; and the Vasogenic Peripheral Edema (VPE) habitat, as the remaining edema of the lesion with the lowest perfusion profile. The results of this thesis have been published in ten scientific contributions, including top-ranked journals and conferences in the areas of Medical Informatics, Statistics and Probability, Radiology & Nuclear Medicine, Machine Learning and Data Mining and Biomedical Engineering. An industrial patent registered in Spain (ES201431289A), Europe (EP3190542A1) and EEUU (US20170287133A1) was also issued, summarizing the efforts of the thesis to generate tangible assets besides the academic revenue obtained from research publications. Finally, the methods, technologies and original ideas conceived in this thesis led to the foundation of ONCOANALYTICS CDX, a company framed into the business model of companion diagnostics for pharmaceutical compounds, thought as a vehicle to facilitate the industrialization of the ONCOhabitats technology.
