论文标题
质膜组织和功能的关键现象
Critical Phenomena in Plasma Membrane Organization and Function
论文作者
论文摘要
质膜平面上的横向组织是生物过程的重要驱动力。过去的十几年已经对脂质组织在调节这种异质性中起着重要作用的观念的实验支持增加了。已经提出了植根于液体液相分离概念的各种生物物理机制，以解释模型和细胞膜中异质性的各种实验观察结果，具有明显但重叠的适用性。在这篇综述中，我们关注的是证据和后果，即质膜已在平衡混溶临界点附近的假设中。关键现象解释了在细胞和模型系统中观察到的异质性的某些特征，但也超越了异质性，以预测其他有趣的现象，包括对组成扰动的反应。
Lateral organization in the plane of the plasma membrane is an important driver of biological processes. The past dozen years have seen increasing experimental support for the notion that lipid organization plays an important role in modulating this heterogeneity. Various biophysical mechanisms rooted in the concept of liquid-liquid phase separation have been proposed to explain diverse experimental observations of heterogeneity in model and cell membranes, with distinct but overlapping applicability. In this review, we focus on evidence for and consequences of the hypothesis that the plasma membrane is poised near an equilibrium miscibility critical point. Critical phenomena explain certain features of the heterogeneity observed in cells and model systems, but also go beyond heterogeneity to predict other interesting phenomena, including responses to composition perturbations.
