论文标题
使用表面等离子体泄漏辐射斑点跟踪单个颗粒
Tracking Single Particles using Surface Plasmon Leakage Radiation Speckle
论文作者
论文摘要
在生物过程的研究中，对小生物粒子（例如蛋白质或病毒）的无标记跟踪是非常有用的，但是这种实验经常受到信号强度弱和对散射杂质的敏感性的阻碍。为了克服这些问题，我们在这里提出了一种新型技术，利用了干涉检测和表面等离子体的强场限制的增强灵敏度。具体而言，我们表明，由分析物粒子散射的场与斑点参考场之间的干扰源自在粗糙金属膜上传播的表面等离子体的随机散射，使粒子跟踪具有子波长度的准确性。我们介绍了我们技术的分析框架，并通过蒙特卡洛模拟验证其对噪声的鲁棒性。
Label free tracking of small bio-particles such as proteins or viruses is of great utility in the study of biological processes, however such experiments are frequently hindered by weak signal strengths and a susceptibility to scattering impurities. To overcome these problems we here propose a novel technique leveraging the enhanced sensitivity of both interferometric detection and the strong field confinement of surface plasmons. Specifically, we show that interference between the field scattered by an analyte particle and a speckle reference field, derived from random scattering of surface plasmons propagating on a rough metal film, enables particle tracking with sub-wavelength accuracy. We present the analytic framework of our technique and verify its robustness to noise through Monte Carlo simulations.
