论文标题
用激光多普勒全息在平面外容器中定量监测的视网膜血流逆转逆转
Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
论文作者
论文摘要
激光多普勒全息图是最近在眼科中引入的平面血液流量成像技术，用于非侵入性地对人类视网膜和脉络膜血流进行图像。在这里，我们提出了一种基于多普勒光谱不对称的数字方法，该方法揭示了相对于平面外容器中光轴的局部血流方向。该定向信息被覆盖在标准灰度血流图像上，以描绘出以红色向相机移动的流动，并以蓝色移动相机，如超声颜色多普勒成像。我们表明，由于反向散射对多普勒光谱的强烈贡献，可以通过高时间分辨率来揭示血流的局部轴向方向，这使我们能够证明病态的血液流动反转。我们还证明了使用光学多普勒光谱图来定量监测视网膜血流逆转。
Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry that reveals the local direction of blood flow with respect to the optical axis in out-of-plane vessels. This directional information is overlaid on standard grayscale blood flow images to depict flow moving towards the camera in red and flow moving away from the camera in blue, as in ultrasound color Doppler imaging. We show that thanks to the strong contribution of backscattering to the Doppler spectrum in out-of-plane vessels, the local axial direction of blood flow can be revealed with a high temporal resolution, which enables us to evidence pathological blood flow reversals. We also demonstrate the use of optical Doppler spectrograms to quantitatively monitor retinal blood flow reversals.
