论文标题

基于RNA的自然通用计算理论

An RNA-Based Theory of Natural Universal Computation

论文作者

Akhlaghpour, Hessameddin

论文摘要

生活面临着各种领域的计算问题,包括动物行为,单细胞行为和胚胎发育。但是,我们目前不知道能够进行普遍计算的自然现有的生物系统,即在范围中等效的生物系统。通用有限维动力系统(包括大多数神经网络模型,细胞内信号级联和基因调节网络)缺乏通用计算,但被认为能够解释认知和发展。我提出了一类模型,该模型从遥远的领域桥接了两个概念:组合性逻辑(或等效地,lambda colculus)和RNA分子生物学。一组基本的RNA编辑规则可以使与图灵机相同的算法复杂性计算任何可计算功能。这些模型并不假设非常复杂的分子机制或与我们已经知道的细胞中发生的任何过程。不同的独立酶可以介导每个规则和RNA分子通过其二级结构解决括号的问题。在这些模型中,最合理的所有编辑规则都可以仅在固定位置相对于预定义主题而在固定位置上实施。这表明通用计算很好地在分子生物学的范围内。因此,可以合理地假设生活已经发展或可能是从尚待发现的通用计算机演变而来的。在许多尺度上,可以使用相同的基于RNA的计算系统来解决各种看似无关的计算问题。对该理论的实验验证可能会极大地影响我们对记忆,认知,发展,疾病,进化和生命早期阶段的理解。

Life is confronted with computation problems in a variety of domains including animal behavior, single-cell behavior, and embryonic development. Yet we currently do not know of a naturally existing biological system that is capable of universal computation, i.e., Turing-equivalent in scope. Generic finite-dimensional dynamical systems (which encompass most models of neural networks, intracellular signaling cascades, and gene regulatory networks) fall short of universal computation, but are assumed to be capable of explaining cognition and development. I present a class of models that bridge two concepts from distant fields: combinatory logic (or, equivalently, lambda calculus) and RNA molecular biology. A set of basic RNA editing rules can make it possible to compute any computable function with identical algorithmic complexity to that of Turing machines. The models do not assume extraordinarily complex molecular machinery or any processes that radically differ from what we already know to occur in cells. Distinct independent enzymes can mediate each of the rules and RNA molecules solve the problem of parenthesis matching through their secondary structure. In the most plausible of these models all of the editing rules can be implemented with merely cleavage and ligation operations at fixed positions relative to predefined motifs. This demonstrates that universal computation is well within the reach of molecular biology. It is therefore reasonable to assume that life has evolved - or possibly began with - a universal computer that yet remains to be discovered. The variety of seemingly unrelated computational problems across many scales can potentially be solved using the same RNA-based computation system. Experimental validation of this theory may immensely impact our understanding of memory, cognition, development, disease, evolution, and the early stages of life.

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源