论文标题
$^{225} $ AC的基于加速器的生产用于癌症治疗
Accelerator Based Production of $^{225}$Ac for Cancer Treatment
论文作者
论文摘要
与$β$ - 发射器相比，有针对性的α疗法可能在杀死肿瘤细胞和对邻近正常细胞的损害方面具有更具体的作用。 $^{225} $ ac以及其他三个$α$发射的女儿$^{221} $ fr，$^{217} $ AT和$^{213} $ po具有明显的临床使用效力。使用MONC代码对$^{225} $ AC的生产路线进行了Monte Carlo模拟，该途径使用具有Thorium-232和radium-226目标的质子加速器可能生成。所有计算都是使用全局模型参数进行的，而无需调整单个目标。该研究表明，在辐射226靶标上的20-30mev能量的质子光束可在一周的辐射中产生$^{225} $ ac活性的1CI。低质子能量的thor辐照会产生较小的$^{225} $ AC活性，但可以从高电流稳定的质子加速器中受益。质子能量为100mev或以上，而当前的数百美元可以产生合理的$^{225} $ AC活动用于实际使用。然而，在低质子能量下，其他共同生产的放射性异构体的污染却少得多，因此低能高电流质子加速器也是产生actinium-225射电射击同位素的可行替代方案。
Targeted Alpha Therapy potentially offers a more specific action in killing tumor cells and less damage to neighbouring normal cells compared to $β$-emitters. $^{225}$Ac along with three other $α$-emitting daughter nuclei $^{221}$Fr, $^{217}$At and $^{213}$Po have significant potency for clinical use. Monte carlo simulation has been carried out using MONC code for production routes of $^{225}$Ac for its possible generation using proton accelerators with Thorium-232 and Radium-226 targets. All the calculations has been carried out using global model parameters without adjusting for individual target. The study reveals that proton beam of 20-30MeV energy with 5$μ$A current on radium-226 target can give rise to 1Ci of $^{225}$Ac activity in a week of irradiation. Thorium irradiation at low proton energy produces smaller $^{225}$Ac activity but one can benefit from high current, stable proton accelerators. Proton energy of 100MeV or above with hundreds of $μ$A current can produce reasonable $^{225}$Ac activity for practical use. However, the contamination of other co-produced radio-isotopes is much less at low proton energy hence low energy high current proton accelerators are also viable alternative to generate Actinium-225 radio isotope.
